These advances led to the discovery of Zn, vitamin C, and many other essential components [7]. Sharquie KE, Najim RA, Al-Hayani RK, Al-Nuaimy AA, Maroof DM (2008) The therapeutic and prophylactic role of oral zinc sulfate in management of recurrent aphthous stomatitis (ras) in comparison with dapsone. For example, contamination with environmental Zn or in test tubes can cause bias [28]. BMC Dermatology 11: 7. ANATOMY AND PHYSIOLOGY OF THE SKIN 3 or stratum spinosum (Murphy, 1997). On the other hand, they also revealed that the Zn was not able to switch from the eumelanogenesis to phaeomelanogenesis. Chodorowska et al., examined and compared Zn contents of hair and serum in 2 groups of patients, one with acne phlegmonosa and another group with alopecia areata. It seems that the sulphate form is better tolerated. Barbarot S, Chantier E, Kuster A, Hello M, Roze JC, et al. It can be used as an effective agent for the treatment of some skin and hair disorders, but generally, it seems that with the exception of the states relating to Zn deficiency, there is very little evidence to support the efficacy of Zn as a first-line treatment for many disorders [61]. The following has been summarized for some of these disorders: Zn supplementations significantly decrease the morbidity and mortality from acute infections and shorten the recovery time. The functions of Zn in human beings can summarily be divided into three categories: catalytic, structural, and regulatory [2,19]. 1977 Jan 14;119(2):37-42. Formulations used in this study increased the Zn concentration in the whole skin and epidermis [47]. J Nutr 130: 1360S-1366S. Zinc Therapy in Dermatology: A Review. Strumia R (2005) Dermatologic signs in patients with eating disorders. Theocharis SE, Margeli AP, Koutselinis A (2003) Metallothionein: a multifunctional protein from toxicity to cancer. Cases in Dermatology Annual Primary Care Conference June 5, 2015 Chong Foo, M.D. The Zn deficiency can be inherited or acquired [2,3,10]. 2004 May;131(5):455-60. In 1973, the association between Zn deficiency and acrodermatitis entropathica (AE) was discovered [8]. However, zinc may be considered as an adjunctive treatment modality. In adults, the body contains about 2 grams of Zn, 20% of which is in the skin and hair [42]. Une zincémie abaissée est notée dans 35 à 45 % des cas, mais n’est symptomatique que dans 10 % des cas environ. Severe zinc deficiency states, such as acrodermatitis enteropathica, are associated with a variety of skin manifestations, such as perioral, acral, and perineal dermatitis. These syndromes can be reversed with systemic zinc repletion. Authoritative facts from DermNet New Zealand. Zn is not teratogenic, so it can be prescribed during pregnancy [8]. Anavekar NS, Williams R, Chong AH (2007) Facial Sweet's syndrome mimicking rosacea fulminans. Topical forms of Zn have been assessed for percutaneous absorption and cutaneous bioavailability [47]. Zn supplementation can be used as adjunctive treatment in many diseases [2]. The role of Zn in human immunity has been summarized in Scheme-1. 2019 Oct 24;49(5):1503-1508. doi: 10.3906/sag-1906-72. MalcolmW. Download .PPT; Linked Article. M.S. King JC, Shames DM, Woodhouse LR (2000) Zinc homeostasis in humans. zinc and vitamin D levels. #zinc #dermatology #zinctherapy #cosmetology #aestheticmedicine #skincare #acne #haircare #prp #antiagingskincare… Wakimoto P, Block G (2001) Dietary intake, dietary patterns, and changes with age: an epidemiological perspective. However, zinc may be considered as an adjunctive treatment modality. Since that time, Zn deficiency has been implicated as a cause for a variety of disorders [2]. Yaghoobi R, Omidian M, Bagherani N (2011) Comparison of therapeutic efficacy of topical corticosteroid and oral zinc sulfate-topical corticosteroid combination in the treatment of vitiligo patients: a clinical trial. For example, higher protein intake results in lower bioavailability of Zn and subsequent decreased Zn absorption [2]. Zinc pyrithione is an antifungal and a common ingredient in shampoos used to treat dandruff due to psoriasis or seborrheic dermatitis. Chodorowska G, Lecewicz-Torun B, Wiercinski J (1990) Study of the zinc content of hair and serum in selected skin diseases. 2007 Sep-Oct;24(5):536-40. doi: 10.1111/j.1525-1470.2007.00512.x. Nausea, vomiting, diarrhea, and temporary pruritus have been described as side effects of oral Zn supplementation [28,58], which are fleeting and dose dependent [8]. In the world, the prevalence of Zn deficiency is estimated at more than 20% [2,4]. Journal Title: Dermatology Research and Practice. 2010 Jul;28(3):547-57. doi: 10.1016/j.det.2010.03.002. 2015 Nov-Dec;77(6):694-704. doi: 10.4103/0250-474x.174989. (1999) Dermatologic correlates of selected metabolic events. They reduce the incidence of acute lower respiratory infection and diarrhea especially in the infants and young children [2]. It is characterized by acquired, idiopathic, progressive and circumscribed hypomelanosis on different parts of the body. Cytarabene causes inflammation of existing seborrheic keratosises 57. Although Zn toxicity is very low, high doses during chronic administration can lead to the marked risk of hypocupremia [8]. In this article, the importance of zinc in human biology and physiology, its pharmacokinetics, causes and manifestations of its deficiency and excess, its therapeutic roles, side effects of zinc supplements and ways for its prevention and treatment have been described. BY DR SIDDHI TIWARI MODERATOR : DR SAROJ PUROHIT 2. DERMATOLOGY AND VENEREOLOGY PAPER.III Time :3 hours DVD/D/11/06/lll Max. On the other hand, animal and seafood proteins are rich in Zn [8,28]. Weinberg's Color Atlas of Pediatric Dermatology, 5e Prose NS, Kristal L. Prose N.S ... Acrodermatitis enteropathica This syndrome results from inadequate absorption or dietary intake of zinc. Zinc supplements must be used with caution in view of the dangers of zinc excess and zinc toxicity. Greaves. Zn supplementations can reduce the absorption of iron, tetracycline, penicillamine and quinolone [28]. Topical % zinc sulphate solution applied once daily for weeks was eective in pityriasis versicolor. (2012) Disseminated lichen planus due to a zinc allergy. Dermatology Center Presentation Free Google Slides theme and PowerPoint template This presentation is perfect to talk about dermatology.The background of this template looks like the different layers of the skin, displaying freckles, lines or pores. 1)Both conditions began simultaneously (neoplasia and paraneoplasia) 2) Development of a parallel course * … The amount of Zn should be expressed as the elemental amount, for example, 5 mg of the Zn sulphate has approximately 1 mg of the elemental Zn [46]. Measuring Zn in the serum as an index of the nutritional Zn status is problematic, because only 0.1% of its stores in the body are contained in the circulation [2]. In January, 2005, a 59-year-old Japanese woman was referred to our hospital with a 5-week history of inflammatory skin lesions on her palms and soles. Would you like email updates of new search results? Journal of Dermatological Treatment: Vol. In addition, Zn loss also occurs via shedding of the epithelial cells, sweat, semen, hair and bleeding during menstruation [2]. Hence, a morning fast is recommended for exact values [28]. Small amounts of this element are lost in the urine and perspiration [1]. Bibi Nitzan Y, Cohen AD (2006) Zinc in skin pathology and care. Dermatology Research and Practice. 2020 Apr 16;2020:6594109. doi: 10.1155/2020/6594109. Presentations. Search for articles by this author. DERMATOLOGY REVIEW Sheryl L. Geisler, MS, PA-C Associate Professor UMDNJ Physician Assistant Program UMDNJ PANCE/PANRE Review Course Based on my mock practice exam results this week, when it comes to dermatology: 30% 50% 1. 4, pp. (2004) Zinc finger protein Zac1 is expressed in chondrogenic sites of the mouse. Some studies have shown that the Cu/Zn ratio in each skin disease reflects the severity of the progress [41]. Kim J, Kim S, Jeon S, Hui Z, Kim Y, Im Y, Lim W, Kim C, Choi H, Kim O. Med Oral Patol Oral Cir Bucal. Marginal Zn deficiency can be considered as a silent factor in the pathogenesis of different systemic and skin diseases, abnormal lymphocytic functions, enhanced susceptibility to infections, prolonged healing, and impaired destruction of free radicals [28]. Zn is required for the structural integrity and binding to DNA in more than 2,000 transcription factors regulating the gene expression [3]. It is important to mention that clinical manifestations resembling AE have been reported in several other nutritional deficiency states such as essential fatty acid, protein and amino acid deficiencies [10]. Pilch SM, Senti FR (1985) Analysis of zinc data from the second National Health and Nutrition Examination Survey (NHANES II). In the early 1900s when advances in biochemistry appeared, many of the essential constituents of nutrition were introduced. It also has roles in pathogenesis of some dermatological disorders. In the structural role, Zn coordinates with certain protein domains, resulting in protein folding and producing structures such as "Zn fingers" [2,20]. CHAPTER 1. HHS About 80% of the plasma Zn is bound to albumin [2]. Hall J1 (2005) Diagnostic dermatology. The homeostasis of Zn is highly regulated by the gastrointestinal tract. Nutritional Zn deficiency affects over 2 billion people in developing countries [2,3], whereas a considerable proportion of the western population is at risk of marginal Zn deficiency [3]. Dermatitis herpetiformis is characterized by intensely itchy, chronic papulovesicular eruptions, usually distributed symmetrically on extensor surfaces (buttocks, back of neck, scalp, elbows, knees, back, hairline, groin, or face). Until the mid 20th century, the importance of Zn in the growth and development of mammals was not recognized. Total parenteral nutrition regimens usually include trace amounts of zinc. Elemental Zn is safe in the dose of 2.5 mg/kg/day (maximum 150mg/day) [28,58]. In the catalytic role, Zn is a critical component of hundreds of the metalloenzymes [2,8,20],  such as alkaline phosphatase, carbonic anhydrase, pancreatic carboxypeptidases, RNA polymerases [2], alcohol dehydrogenase [2,9], DNA and RNA nucleotidyl transferases, glutamic, lactic and malic dehydrogenase and δ-aminolevulinic acid dehydratase [9]. Greene HL, Hambidge KM, Schanler R, Tsang RC (1988) Guidelines for the use of vitamins, trace elements, calcium, magnesium, and phosphorus in infant and children receiving total parenteral nutrition: report of the Subcommittee on Pediatric Parenteral Nutrient Requirements from the Committee on Clinical Practice Issues of the American Society for Clinical Nutrition. Regulation, it is characterized by acquired, idiopathic, progressive and circumscribed hypomelanosis different!: an overview of zinc metabolism ( ppt ) template and background for dermatology ppt.... 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